HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dichloromethane → Methyl 4-bromo-4-(chlorobenzoyl)butyrate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dichloromethane | HCID 6344 | — |
| Reactant | Bromine | HCID 24408 | — |
| Reactant | Methyl 5-(4-chlorophenyl)-5-oxovalerate | HCID 10966649 | — |
| Product | Methyl 4-bromo-4-(chlorobenzoyl)butyrate | HCID 18376473 | 96% |
Reaction Steps
Bromine (46.5 g) was added dropwise to a dichloromethane (400 ml) solution of methyl 4-(4-chlorobenzoyl)butyrate (70.0 g). After stirring for 15 minutes, the reaction mixture was washed with water, dried (MgSO4), and concentrated to obtain methyl 4-bromo-4-(chlorobenzoyl)butyrate (89.5 g, 96%) as an oily substance. NMR (δ ppm in CDCl3): 2.3-2.7(4H,m), 3.71(3H,s), 5.33(1H,dd,J=8&5.5Hz), 7.48(2H,d,J=8.5Hz), 7.98(2H,d,J=8.5Hz).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06498179B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-b417f0f5c2014b01b8a9d9567973dec5 |
| Source note | uspto-grants-2002_12 |