2-Methylimidazole → HCID 54455876, compound

Participants

Reaction Steps

Sodium hydride(oil, 60%, 710 mg) was gradually added to a mixture of ethyl 2-(2-chloro-4-[4-chlorophenyl)-5-oxazolyl]-2-oxoacetate(4.63 g), 2-methylimidazole(1.45 g) and N,N-dimethylformamide(50 ml) at 0° C. After stirring for 1 hour at room temperature, the reaction mixture was poured into ice water to give ethyl 2-[4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolyl]-2-oxoacetate(3.12 g, 59%). This was recrystallized from ethyl acetate-hexane to give colorless prisms. mp 126-127° C.

Provenance & Evidence