Hydrochloric Acid → 2-Chloro-4-(4-chlorophenyl)-5-oxazolepropionic acid

Participants

Reaction Steps

An aqueous solution of 1 N sodium hydroxide (34 ml) was dropwise added to an ethanol (50 ml) solution; of methyl 2-chloro-4-(4-chlorophenyl)-5-oxazolepropionate (8.50 g), with cooling with ice. After stirring for 20 minutes with cooling and then for 30 minutes at room temperature, 2 N hydrochloric acid was added thereto, and the crystals thus precipitated were collected by filtration to obtain 2-chloro-4-(4-chlorophenyl)-5-oxazolepropionic acid (8.00 g, 99%) This was recrystallized from ethyl acetate to give colorless prisms. mp 169-170° C.

Provenance & Evidence