HuagongsheHuagongshe Chemistry Print Report · For research reference only
3,5-Dimethylpyrazole → 4-(4-Chlorophenyl)-2-(3,5-dimethyl-1-pyrazolyl)-5-oxazolepropionic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3,5-Dimethylpyrazole | HCID 6210 | — |
| Reactant | Methyl 3-[2-chloro-4-(4-chlorophenyl)-5-oxazolyl]propionate | HCID 10990225 | — |
| Product | 4-(4-Chlorophenyl)-2-(3,5-dimethyl-1-pyrazolyl)-5-oxazolepropionic acid | HCID 21088628 | 90% |
Reaction Steps
In the same manner as in Example 30, obtained was: 4-(4-chlorophenyl)-2-(3,5-dimethyl-1-pyrazolyl)-5-oxazolepropionic acid (yield: 90%) by reaction of methyl 2-chloro-4-(4-chlorophenyl)-5-oxazolepropionate with 3,5-dimethylpyrazole followed by hydrolysis of the resulting product. This was recrystallized from ethanol to give colorless needles. mp 201-202° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06498179B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-92e8bdbd913d4b13a4bdef6f28573573 |
| Source note | uspto-grants-2002_12 |