Sodium hydride → HCID 18376462, compound

Participants

Reaction Steps

Sodium hydride (60% dispersion in oil, 265 mg) was gradually added to a solution of N-(2-chloroethyl)-4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolepropionamide (1.30 g) in N,N-dimethylformamide (30 ml), at room temperature. After stirring at room temperature for 3 hours, the reaction mixture was poured into ice water, and then extracted with ethyl acetate. The ethyl acetate layer was washed with water, and dried (MgSO4), and the solvent was evaporated. The crystals thus precipitated were collected by filtration to obtain 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-[2-(2-oxazolin-2-yl)ethyl]oxazole (1.07 g, 91%). This was recrystallized from acetone-isopropyl ether to give colorless prisms. mp 119-120° C.

Provenance & Evidence