Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Methylimidazole | HCID 12749 | — |
| Reactant | HCID 11099941 | HCID 11099941 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 11132852 | HCID 11132852 | 88% |
Reaction Steps
A mixture of ethyl 2-chloro-4-(4-chlorophenyl)-5-oxazolepentanoate(10.0 g), 2-methylimidazole(7.20 g), potassium carbonate(12.1 g) and N,N-dimethylformamide(80 ml) was stirred for 2 hours at 120-130° C. Water was added to the reaction mixture to give ethyl 4-(4-chlorophenyl)-2-(2-methyl-1-imidazolyl)-5-oxazolepentanoate(9.97 g, 88%). This was recrystallized from ethyl acetate-isopropyl ether to give colorless prisms. mp 93-94° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06498179B1 |
|---|
| Source dataset | uspto-grants-2002_12 |
|---|
| ORD ID | ord-c3d9066082a24204b362b85d05ba638a |
|---|
| Source note | uspto-grants-2002_12 |
|---|
