Ammonia → HCID 18374571, compound

Participants

Reaction Steps

930 mg of 4-[1-(4-fluorophenyl)-3-(3-hydroxy-3-phenylpropyl)-4-oxo-azetidin-2-yl]-benzonitrile, dissolved in 100 ml of ethanol, are admixed with 4 ml of conc. ammonia and hydrogenated for 20 hours over Raney Ni, at room temperature and a hydrogen pressure of 20 bar. The catalyst is filtered off and the filtrate is concentrated under reduced pressure, giving, after chromatography (SiO2, dichloromethane/methanol=0:1), the product of molecular weight 404.5 (C25H25FN2O2); MS (DCl+): 405 (M+H+), 387 (M+H+−H2O).

Provenance & Evidence