Adipic Acid → HCID 18374588, compound

Participants

Reaction Steps

2 g of 5-(3-aminophenyl)-3-butyl-7-dimethylamino-3-ethyl-1,1-dioxo-2,3,4,5-tetra-hydro-1H-benzo[b]thiepin-4-ol, 3.4 g of hexanedioic acid, 1.04 g of dicyclohexylcarbodiimide and 640 mg of benzotriazol-1-ol in 80 ml of tetrahydrofuran are stirred at room temperature overnight. The mixture is concentrated, the residue is taken up in ethyl acetate, excess urea is removed by filtration and the mixture is washed with water. The residue of the dried organic phase is purified by column filtration (SiO2, dichloromethane/methanol=20:1). This gives the product of molecular weight 558.7 (C30H42N2O6S); MS (ESI+): 559 (M+H+).

Provenance & Evidence