Diisopropylcarbodiimide → HCID 18374603, compound

Participants

Reaction Steps

55 mg of 4-(4-aminomethylphenyl)-1-(4-fluorophenyl)-3-[3-(4-fluorophenyl)-3-hydroxypropyl]azetidin-2-one are added to a solution of 40 mg of (2-{2-[3-(3-butyl-7-dimethylamino-3-ethyl-4-hydroxy-1,1-dioxo-2,3,4,5-tetrahydro-1H-benzo[b]thiepin-5-yl)phenylamino]ethoxy}ethoxy)acetic acid compound with trifluoroacetic acid, 37 μl of diisopropylcarbodiimide, 26 mg of hydroxybenzotriazole and 40 μl of triethylamine in 2 ml of dimethylformamide, and the mixture is stirred for 12 h. The reaction solution is concentrated and separated by HPLC (Merck-Hibar-Lichrospher 100-RP-18, water (0.1% trifluoroacetic acid)/acetonitrile (0.1% trifluoroacetic acid)=80/20→10/90).

Provenance & Evidence