1-Phenethylamine, (-)- → HCID 9926914, compound

Participants

Reaction Steps

A solution of 2-methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine (0.203 g, 0.74 mmol) and (S)-1-phenylethylamine (0.15 mL, 1.16 mmol) in 2 mL of xylenes was heated to 100° C. After 8 h, the reaction mixture was concentrated and purified by chromatography (silica, 1:1 hexanes: EtOAc, then 1:1 CH2Cl2: EtOAc) to give 0.133 g of the title compound. 1H NMR (500 MHz, CDCl3): δ 8.49 (br s, 1H); 8.39 (d, J=5.5 Hz, 1H); 7.83 (d, J=8.0 Hz, 1H); 7.3-7.5 (m, 8H); 6.79 (d, J=5.5 Hz, 1H); 5.75 (br s, 1H); 5.21 (br s, 1H); 1.65 (d, J=6.9 Hz, 3H).

Provenance & Evidence