Benzo-1,3-dioxole-5-methylamine → HCID 18375888, compound

HRID 2300724Notes

Reaction equation

HRID 2300724 reaction equation
CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[CH2:20]([NH2:30])[C:21]1[CH:29]=[CH:28][C:27]2[O:26][CH2:25][O:24][C:23]=2[CH:22]=1>>[CH2:25]1[O:26][C:27]2[CH:28]=[CH:29][C:21]([CH2:20][NH:30][C:5]3[N:10]=[C:9]([N:11]4[C:15]5[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=5[N:13]=[CH:12]4)[CH:8]=[CH:7][N:6]=3)=[CH:22][C:23]=2[O:24]1

Participants

3

Reactant 2

HCID 75799Benzo-1,3-dioxole-5-methylamineHCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 18375888HCID 18375888, compound

Procedure

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with piperonylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (ESI): m/e 346.2 (M+1). 1H NMR (500 MHz, CDCl3): δ 8.61 (s, 1H); 8.42 (br s, 1H); 8.11 (br s, 1H); 7.86 (m, 1H); 7.38 (m, 2H); 6.89 (m, 2H); 6.83 (m, 2H); 5.97 (s, 2H); 5.79 (br s, 1H); 4.65 (d, J=5.7 Hz, 2H).

Sources & evidence

ORD record
ord-dec6949f0c6b4b02b60f79d8fecef6ec
Source dataset
uspto-grants-2002_12
Patent number
US06498165B1

Reaction notes

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