Benzenemethanamine, 3,4-dichloro- → HCID 18375450, compound

HRID 2300740Notes

Reaction equation

HRID 2300740 reaction equation
CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[Cl:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][C:28]=1[Cl:29])[CH2:24][NH2:25]>>[Cl:20][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][C:28]=1[Cl:29])[CH2:24][NH:25][C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1

Participants

3

Reactant 2

HCID 1608Benzenemethanamine, 3,4-dichloro-HCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 18375450HCID 18375450, compound

Procedure

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with 3,4-dichlorobenzylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (ESI): m/e 370.1 (M+1). 1H NMR (500 MHz, CDCl3): δ partial 8.58 (s, 1H); 8.43 (d, J=5.0 Hz, 1H); 8.01 (br s, 1H); 7.85 (d, J=8.7 Hz, 1H); 7.52 (d, J=1.6 Hz, 1H); 7.25 (m, 1H); 6.87 (d, J=5.5 Hz, 1H); 6.00 (br s, 1H); 4.71 (d, H=6.0 Hz, 2H).

Sources & evidence

ORD record
ord-d8dde328743d47048e4f2148bb43d3e0
Source dataset
uspto-grants-2002_12
Patent number
US06498165B1

Reaction notes

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