2-Chloro-6-methylbenzylamine → 2-[2-Chloro-6-methylbenzylamino]-4-[benzimidazol-1-yl]pyrimidine

Participants

Reaction Steps

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with 2-chloro-6-methylbenzylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (EI): m/e 350.3 (M+1). 1H NMR (500 MHz, CDCl3): δ 8.66 (s, 1H); 8.40 (br s, 1H); 8.21 (s, 1H); 7.87 (d, J=7.6 Hz, 1H); 7.40 (m, 2H); 7.30 (d, J=8.0 Hz, 1H); 7.17 (m, 2H); 6.85 (d, J=5.5 Hz, 1H); 5.56 (br s, 1H); 4.90 (d, J=5.0 Hz, 2H); 2.51 (s, 3H).

Provenance & Evidence