Cyclohexanemethylamine → HCID 9948519, compound

HRID 2300760Notes

Reaction equation

CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[NH2:20][CH2:21][CH:22]1[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1>>[CH:22]1([CH2:21][NH:20][C:5]2[N:10]=[C:9]([N:11]3[C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=4[N:13]=[CH:12]3)[CH:8]=[CH:7][N:6]=2)[CH2:27][CH2:26][CH2:25][CH2:24][CH2:23]1

Participants

Reactant 2

HCID 76688Cyclohexanemethylamine

HCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 9948519HCID 9948519, compound

Procedure

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with aminomethylcyclohexane according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (ESI): 308.3 (M+1). 1H NMR (500 MHz, CDCl3): δ 8.64 (s, 1H); 8.39 (br s, 1H); 8.23 (br s, 1H); 7.87 (m, 1H); 7.41 (m, 2H); 6.78 (d, J=5.5 Hz, 1H); 5.50 (br s, 1H); 3.39 (t, J=6.3 Hz, 2H) 1.70-1.93 (m, 6H); 1.18-1.38 (m, 3H); 1.02-1.12 (m, 2H).

Sources & evidence

ORD record: ord-9d3fe3098149428eb08e3bf0c777541b
Source dataset: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06498165B1

Reaction notes

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