(S)-1-(p-tolyl)ethanamine → HCID 59924659, compound

HRID 2300764Notes

Reaction equation

HRID 2300764 reaction equation
CS([C:5]1[N:10]=[C:9]([N:11]2[C:15]3[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=3[N:13]=[CH:12]2)[CH:8]=[CH:7][N:6]=1)(=O)=O.[CH3:20][C:21]1[CH:26]=[CH:25][C:24]([C@@H:27]([NH2:29])[CH3:28])=[CH:23][CH:22]=1>>[CH3:20][C:21]1[CH:26]=[CH:25][C:24]([C@@H:27]([NH:29][C:5]2[N:10]=[C:9]([N:11]3[C:15]4[CH:16]=[CH:17][CH:18]=[CH:19][C:14]=4[N:13]=[CH:12]3)[CH:8]=[CH:7][N:6]=2)[CH3:28])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 7015759(S)-1-(p-tolyl)ethanamineHCID 155496402-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine

Product 1

HCID 59924659HCID 59924659, compound

Procedure

2-Methanesulfonyl-4-[benzimidazol-1-yl]pyrimidine was reacted with (S)-1-(4-methylphenyl)ethylamine according to the procedure described in EXAMPLE 1, Step C to afford the title compound. Mass Spectrum (ESI): m/e 330.3 (M+1). 1H NMR (500 MHz, CDCl3): δ partial 8.53 (s, 1H); 8.39 (d, J=5.3 Hz, 1H), 7.84 (d, J=8.3 Hz, 1H); 6.78 (d, J=5.5 Hz, 1H); 5.75 (br s, 1H); 5.20 (br s, 1H); 2.36 (s, 3H); 1.63 (d, J=6.8 Hz, 3H).

Sources & evidence

ORD record
ord-dea61cbf5c05410090ba9d06209245fd
Source dataset
uspto-grants-2002_12
Patent number
US06498165B1

Reaction notes

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