Aniline → HCID 18375635, compound

HRID 2300788Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:8]1([C@@H:14]([NH:16][C:17]2[N:22]=[C:21]([N:23]3[C:27]4[CH:28]=[C:29]([C:32]([OH:34])=O)[CH:30]=[CH:31][C:26]=4[N:25]=[CH:24]3)[CH:20]=[CH:19][N:18]=2)[CH3:15])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>>[C:8]1([CH:14]([NH:16][C:17]2[N:22]=[C:21]([N:23]3[C:27]4[CH:28]=[C:29]([C:32]([NH:1][C:2]5[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=5)=[O:34])[CH:30]=[CH:31][C:26]=4[N:25]=[CH:24]3)[CH:20]=[CH:19][N:18]=2)[CH3:15])[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

Reactant 2

HCID 6115Aniline

HCID 69961483HCID 69961483, compound

Product 1

HCID 18375635HCID 18375635, compound

Procedure

The title compound was prepared from aniline and 2-[(S)-1-phenylethylamino]-4-[6-carboxy-benzimidazol-1-yl]pyrimidine according to the procedure described in EXAMPLE 107. Partial 1H NMR (500 MHz CD3OD): δ 8.72 (br, 1H); 8.55 (br, 1H); 8.32 (br, 1H); 8.18 (s, 1H); 7.83 (d J=7.5 Hz, 1H); 7.76 (d J=7.5 Hz, 1H); 7.70 (d J=7.0 Hz, 2H); 6.78 (δ J=5.0 Hz, 1H); 5.23 (br, 1H); 1.63 (d J=6.0 Hz, 3H).

Sources & evidence

ORD record: ord-0a4d7dd283ff43388535c6dd244bb6c0
Source dataset: uspto-grants-2002_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06498165B1

Reaction notes

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