Tributylvinyltin → HCID 59924954, compound

Participants

Reaction Steps

The title compound was prepared from 44 mg of 2-[(S)-1-phenylethylamino]-4-[5-iodobenzimidazol-1-yl]pyrimidine, 87 μL tributylstannyl ethylene and 1.15 mg Pd(PPh3)4 using the procedure described in EXAMPLE 273 to give 8.5 mg of the title compound. RF: 0.45 (5% MeOH in CH2Cl2). 1H NMR (500 MHz, 1:1 CD3OD/CDCl3): δ 1.59 (d, J=6.8 Hz, 3H), 5.13 (m, 1H), 5.24 (d, J=11.2 Hz, 1H), 5.76 (d, J=17.4 Hz, 1H), 6.79 (dd, J=17.6, 11 Hz, 1H), 6.87 (d, J=5.7 Hz, 1H), 7.21 (br s, J=7.3 Hz, 1H), 7.27-7.34 (m, 3H), 7.41 (br s, J=7.3 Hz, 2H), 7.6-7.8 (m, 1H), 7.67 (br s, 1H), 8.31 (br s, J=5.7 Hz, 1H), 8.55-8.7 (m, 1H). Mass Spectrum (CH3CN-TFA-NH4HCO2-ESI): 342.3 (M+1).

Provenance & Evidence