Chloro-N,N-dimethylformiminium chloride → HCID 86758757, compound

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Reaction Steps

To a solution of 2-[(S)-1-phenylethylamino]-4-hydroxy-6-methylpyrimidine (100 mg, 0.436 mmol, 1 eq) in chloroform (2 mL) was added (chloromethylene)dimethylammonium chloride (Vilsmeier reagent) (55.9 mg, 0.436 mmol, 1 eq). After 1 hour the solvent was removed under reduced pressure. The product was purified by silica gel chromatography (eluted with 3:1 hexanes/acetone) to give 19.8 mg of the title compound. Mass spectrum (NH3/CI): 248.1 (M+1).

Provenance & Evidence