HCID 68453426, compound → HCID 59924695, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-[(S)-1-phenylethylamino]-4-chloro-6-methylpyrimidine (11 mg, 0.044 mmol, 1 eq) in DMF (0.2 mL) was added a solution of benzimidazole sodium salt (0.088 mL of a 1M solution, 0.088 mmol, 2 eq). The mixture was warmed to 100° C. for 2 h. The mixture was cooled and the DMF was removed under reduced pressure. The residue was purified by preparative thin layer chromatography (eluted with 2:1 hexanes/acetone to give 9.9 mg of the title compound. 1H NMR (500 MHz, CDCl3): δ 1.23 (3H, d, J=7 Hz), 2.45 (3H, s), 5.2 (1H br s), 5.62 (1H, br s), 6.6 (1H, s), 7.2-7.5 (7H, m), 7.8 (2H, d, J=8 Hz), 8.46 (1H, br s). Mass spectrum (NH3/CI): 330.1 (M+1).

Provenance & Evidence