HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methylphenyl boronic acid → 2-[1-(3-Nitrophenyl)ethylamino]-4-[benzimidazol-1-yl]-6-(2-methylphenyl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methylphenyl boronic acid | HCID 2733267 | — |
| Reactant | 2-[1-(3-Nitrophenyl)ethylamino]-4-[benzimidazol-1-yl]-6-chloropyrimidine | HCID 18375781 | — |
| Reactant | TFA acetonitrile | HCID 21924481 | — |
| Catalyst | Bis(cyclopenta-1,4-dien-1-yl(diphenyl)phosphane);dichloropalladium;iron(2+) | HCID 178418228 | — |
| Product | 2-[1-(3-Nitrophenyl)ethylamino]-4-[benzimidazol-1-yl]-6-(2-methylphenyl)pyrimidine | HCID 18375550 | — |
Reaction Steps
The title compound was prepared from 2-[1-(3-nitrophenyl)ethylamino]-4-[benzimidazol-1-yl]-6-chloropyrimidine and 2-methylphenylboronic acid according to the precedure described in EXAMPLE 306, Step C and using [1,1′-bis(diphenylphosphino)-ferrocene]dichloropalladium(II) as catalyst. Mass spectrum (CH3CN/TFA/NH4O2CH/ESI) 451.3 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06498165B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-aefb106a1e5e4dd0972cc1f11bd6f724 |
| Source note | uspto-grants-2002_12 |