HuagongsheHuagongshe Chemistry Print Report · For research reference only
Furan-3-boronic acid → 2-[1-(3-Nitrophenyl)ethylamino]-4-[benzimidazol-1-yl]-6-(furan-3-yl)pyrimidine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Furan-3-boronic acid | HCID 2734358 | — |
| Reactant | 2-[1-(3-Nitrophenyl)ethylamino]-4-[benzimidazol-1-yl]-6-chloropyrimidine | HCID 18375781 | — |
| Reactant | TFA acetonitrile | HCID 21924481 | — |
| Product | 2-[1-(3-Nitrophenyl)ethylamino]-4-[benzimidazol-1-yl]-6-(furan-3-yl)pyrimidine | HCID 18375825 | — |
Reaction Steps
The title compound was prepared from 2-[1-(3-nitrophenyl)ethylamino]-4-[benzimidazol-1-yl]-6-chloropyrimidine and furan-3-boronic acid according to the precedure described in EXAMPLE 306, Step C and using [1,1′-bis(diphenylphosphino)ferrocene]-dichloropalladium(H) as catalyst. Mass spectrum (CH3CN/TFA/NH4O2CH/ESI) 427.0 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06498165B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-aeced99b664c4c0482dd1ecee15a26d3 |
| Source note | uspto-grants-2002_12 |