Trifluoroacetic acid → HCID 18375538, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-[1-(1-N-tert-butoxycarbonyl-indol-3-yl)ethylamino]-4-[benzimidazol-1-yl]pyrimidine (25 mg, 0.055 mmol) in methylene chloride (0.25 ml) was added TFA (0.25 ml). The reaction mixture was stirred at 0° C. for an hour and room temperature for 30 min. The solvents were concentrated in vacuo. The crude product was purified by preparative thin layer chromatography eluting with 5% 2M NH3 in MeOH/CH2Cl2 to give 6 mg of the title compound. Mass spectrum (ESI) 355.3 (M+1).

Provenance & Evidence