5-Amino-4,6-dichloropyrimidine → HCID 18342788, compound

HRID 2300873Notes

Reaction equation

HRID 2300873 reaction equation
[C:1]1([C@@H:7]([NH:9][C:10]2[N:15]=[C:14]([N:16]3[C:20]4[CH:21]=[CH:22][C:23]([Sn](C)(C)C)=[CH:24][C:19]=4[N:18]=[CH:17]3)[CH:13]=[CH:12][N:11]=2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[NH2:29][C:30]1[C:31]([Cl:37])=[N:32][CH:33]=[N:34][C:35]=1Cl>>[C:1]1([C@@H:7]([NH:9][C:10]2[N:15]=[C:14]([N:16]3[C:20]4[CH:21]=[CH:22][C:23]([C:35]5[C:30]([NH2:29])=[C:31]([Cl:37])[N:32]=[CH:33][N:34]=5)=[CH:24][C:19]=4[N:18]=[CH:17]3)[CH:13]=[CH:12][N:11]=2)[CH3:8])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

3

Reactant 2

HCID 794345-Amino-4,6-dichloropyrimidineHCID 69963704HCID 69963704, compound

Product 1

HCID 18342788HCID 18342788, compound

Procedure

The title compound was prepared according to the procedure described in EXAMPLE 424, starting from 2-[(S)-1-Phenylethylamino]-4-[5-trimethylstannylbenzimidazol-1-yl]pyrimidine and 5-amino-4,6-dichloropyrimidine. Mass spectrum (ESI) 443.4 (M+).

Sources & evidence

ORD record
ord-94f5ad582c7041febf2562b19be83e68
Source dataset
uspto-grants-2002_12
Patent number
US06498165B1

Reaction notes

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