Dimethyl Sulfoxide → HCID 69962563, compound

Participants

Reaction Conditions

Reaction Steps

2-[(S)-1-Phenylethylamino]-4-[5-(2-chloropyrimidin-4-yl)benzimidazol-1-yl]pyrimidine (EXAMPLE 424) (80 mg), 3,4,5-trimethoxybenzylamine hydrochloride (219 mg), and N,N-diisopropylethylamine (0.16 mL) were dissolved DMSO (4 mL) and the resulting solution was heated to 100° C. for 15 hours. Upon cooling the reaction mixture was diluted with water (20 mL) and extracted with EtOAc (2×25). The combined organic extracts were dried (MgSO4) and evaporated.

Provenance & Evidence