HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Methoxyaniline → HCID 59924726, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Methoxyaniline | HCID 7000 | — |
| Reactant | 2-Dimethylaminopyridine | HCID 21885 | — |
| Reactant | 1,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochloride | HCID 2723939 | — |
| Reactant | HCID 69962054 | HCID 69962054 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Solvent | Triethylamine | HCID 8471 | — |
| Product | HCID 59924726 | HCID 59924726 | 30.6% |
Reaction Steps
2-[(S)-1-(3-carboxyphenyl)ethylamino]-4-[benzimidazol-1-yl]pyrimidine (EXAMPLE 58, 23.0 mg) and o-anisidine (22 μL, 0.20 mmol) were mixed in CH2Cl2 (2 mL) under nitrogen. Triethylamine (45 μL), 1-(3-dimethylaminopropyl)-3-ethylcarbodiimide hydrochloride (38.5 mg) and dimethylaminopyridine (approx. 1 mg) were added and the mixture stirred at room temperature. After 19 h the mixture was concentrated in vacuo then eluted directly on silica gel (2:1 hexanes:acetone to 1:1 hexanes:acetone) to yield 9.1 mg of the title compound. Mass spectrum (ESI) 465.2 (M+1).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06498165B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-e58a5d0ffe034b3cb0fa93bf9ed3b65a |
| Source note | uspto-grants-2002_12 |