HCID 70156156, compound → HCID 70021766, compound

HRID 2300957Notes

Reaction equation

HRID 2300957 reaction equation
[NH2:1][C@@H:2]1[C:11]([CH3:13])([CH3:12])[C:10]2[CH:9]=[C:8]([OH:14])[CH:7]=[CH:6][C:5]=2[CH2:4][C@H:3]1[S:15][C:16]1[CH:21]=[CH:20][C:19](O)=[CH:18][CH:17]=1.N[C@@H:24]1[C:33](C)(C)C2C=C(O)C=CC=2[CH2:26][C@H:25]1SC1C=CC(N)=CC=1.N[C@@H]1C(C)(C)C2C=C(O)C=CC=2C[C@H]1SC1C=CC=C(O)C=1.C(OC(=O)CCS[C@H]1[C@H](N)C(C)(C)C2C(=CC=C(O)C=2)C1)C.N[C@@H]1C(C)(C)C2C=C(O)C=CC=2C[C@H]1SCCC1C=CC=CC=1.N[C@@H]1C(C)(C)C2C(=CC=C(O)C=2)C[C@H]1SC(C)C(N)=O.N[C@@H]1C(C)(C)C2C(=CC=C(O)C=2)C[C@H]1SCCC(O)=O.N[C@@H]1C(C)(C)C2C(=CC=C(O)C=2)C[C@H]1SCCC(NC(CC1C=CC(O)=CC=1)C(N)=O)=O>>[NH2:1][C@@H:2]1[C:11]([CH3:12])([CH3:13])[C:10]2[CH:9]=[C:8]([OH:14])[CH:7]=[CH:6][C:5]=2[CH2:4][C@H:3]1[S:15][C:16]1[CH:21]=[CH:20][C:19]2[C:18](=[CH:33][CH:24]=[CH:25][CH:26]=2)[CH:17]=1

Participants

9

Reactant 8

HCID 70156156HCID 70156156, compound2×HCID 70156722HCID 70156722, compound2×HCID 70156883HCID 70156883, compound2×HCID 70157087HCID 70157087, compound2×HCID 70157734HCID 70157734, compound2×HCID 70158113HCID 70158113, compound2×HCID 70158457HCID 70158457, compound2×HCID 86758750HCID 86758750, compound2×

Product 1

HCID 70021766HCID 70021766, compound

Procedure

Trans7-Amino-6-(4-hydroxy-phenylsulfanyl)-8,8-dimethyl-5,6,7,8-tetrahydro-naphthalen-2-ol (Compound #36);Trans-7-amino-6-(4amino-phenylsulfanyl)-8,8-dimethyl-5,6,7,8-tetrahydro-naphthalen-2-ol (Compound #37);Trans-7-amino-6-(3-hydroxy-phenylsulfanyl)-8,8-dimethyl-5,6,7,8-tetrahydro-naphthalen-2-ol (Compound #38);Trans-3-(3-Amino-6-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydro-naphthalen-2-ylsulfanyl)-propionic acid ethyl ester (Compound #39);Trans-7-amino-8,8-dimethyl-6-phenethylsulfanyl-5,6,7,8-tetrahydronaphthalen-2-ol (Compound #40);Trans-2-(3-amino-6-hydroxy-4,4-dimethyl 1,2,3,4-tetrahydronaphthalen-2-ylsulfanyl)-propionamide (Compound #41);Trans-3-(3-amino-6-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydro-naphthalen-2-ylsulfanyl)-propionic acid (Compound #42);Trans-2-[3-(3-Amino-6-hydroxy-4,4-dimethyl-1,2,3,4-tetrahydro-naphthalen-2-ylsulfanyl)-propionylamino]-3-(4-hydroxy-phenyl)-propionamide (Compound #43); 3-trans-(2-ethoxycarbonyl-ethylsulfanyl)-1,1-diethyl-7-hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl (Compound #44); 3-trans-(2-carboxy-ethylsulfanyl)-1,1-diethyl-7-hydroxy-1,2,3,4-tetrahydro-naphthalen-2-yl (Compound #45);

Sources & evidence

ORD record
ord-37e2199e583e4dc79abe8ce97cdbcb47
Source dataset
uspto-grants-2002_12
Patent number
US06498196B1

Reaction notes

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