反应详情

温度

40 °C

A mixture of 5.6 g (0.05 mole) of 2-mercaptopyridine, 3.3 g (0.05 mole) of potassium hydroxide (85% pellets), 35 ml of ethanol and 5 ml of water was prepared. To this mixture was added 7.8 g (0.05 mole) of 2,5-dimethyl-benzylchloride, while maintaining good stirring. The mixture was stirred and heated to 40° C. for 45 minutes, cooled to room temperature, and then added to 150 ml of water. The aqueous mixture was extracted with 150 ml of diethyl ether; the ether phase washed with 150 ml of water. Finally, the ether phase was dried with anhydrous sodium sulfate. Removal of the ether left a green oil. An infrared spectrum was consistent with the structure of 2-((2,5-dimethylphenyl)methylthio) pyridine.

1. customwas prepared
2. temperaturewhile maintaining good stirring
3. temperaturecooled to room temperature
4. extractionThe aqueous mixture was extracted with 150 ml of diethyl ether
5. washthe ether phase washed with 150 ml of water
6. dry with materialFinally, the ether phase was dried with anhydrous sodium sulfate
7. customRemoval of the ether
8. waitleft a green oil