Trifluoroacetic acid → HCID 69749755, compound

Participants

Reaction Steps

TFA (0.5 ml) was added drop wise to a solution of (R)-N-[2-chloro-4-(phenylsulphonyl)phenyl]-2-(t-butoxycarbonylamino)propanamide (Method 2) (0.090 g) in dry DCM (5 ml). The resulting mixture was stirred at room temperature for 3 hours. Volatile material was removed by evaporation. The resulting residue was re-dissolved in DCM (10 ml), and volatile material was removed by evaporation. This was repeated, the resulting residue was dried for 30 minutes on a high vacuum line. The residue was then dissolved in DCM and passed through a Varian Isolute SPE column containing basic residues, with DCM as the eluent to give the title compound (0.067 g) as a gum. NMR (CDCl3): 1.32-1.40 (d, 3H), 1.52 (brs, 2H), 3.51-3.64 (q, 1H), 7.40-7.55 (m, 3H), 7.71-7.8(m, 1H), 7.81-7.95 (m, 3H), 8.58-8.65 (m, 1H), 10.46 (brs, 1H). MS: (ESP−) 339.3 (M+H)+.

Provenance & Evidence