Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Urea | HCID 1176 | — |
| Reactant | Benzoic acid, 2-amino-5-iodo- | HCID 72911 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | 6-iodo-1H-quinazoline-2,4-dione | HCID 11380668 | 87.4% |
Reaction Steps
A mixture of 2-amino-5-iodobenzoic acid (3.5 g) and urea (1.56 g) in NMP (15 ml) was heated at 160° C. for 6 hours then cooled. Water (200 ml) was added and the resultant precipitate was collected, washed with water and dried to give the title compound (3.35 g) as a solid. MS (CI): 289 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06498275B1 |
|---|
| Source dataset | uspto-grants-2002_12 |
|---|
| ORD ID | ord-55b39c4db08a431c9102d98fe03163de |
|---|
| Source note | uspto-grants-2002_12 |
|---|
