Potassium Carbonate → HCID 9887186, compound

Participants

Reaction Steps

A 168 mg (0.98 mmol) portion of 2,3,4,9-tetrahydro-1H-pyrido[3,4-b]indole and 269 mg (1.96 mmol) of potassium carbonate were added to 3 ml of DMF solution containing 150 mg (0.49 mmol) of 2a-(4-bromobutyl)-2a,3,4,5-tetrahydro-1H-benz[cd]indol-2-one and stirred overnight at room temperature. The reaction solution was extracted with chloroform and washed with water. After drying (Na2SO4), the solvent was removed by evaporation under a reduced pressure and the residue was recrystallized from acetone to obtain 98 mg of the title compound (48% in yield). An oily material obtained by concentrating the mother liquid was purified by a silica gel column chromatography (30 cc; elution by chloroform-methanol=15:1) to obtain 73 mg of the title compound (38% in yield).

Provenance & Evidence