tert-Butyl 4-oxopiperidine-1-carboxylate → tert-butyl 3-[(dimethylamino)methylene]-4-oxotetrahydro-1(2H)-pyridinecarboxylate

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Reaction Steps

N-t-Butoxycarbonyl-4-piperidone (3.0 g, 15 mmol) was dissolved in N,N-dimethylformamide dimethylacetal (15 ml) and heated under reflux for 1 hour. The solvent was removed by evaporation from the reaction solution under a reduced pressure, and the thus obtained material was separated and purified by a silica gel column chromatography to obtain 1.3 g (5.2 mmol, 34% in yield) of the title compound.

Provenance & Evidence