Methanol → HCID 18377344, compound

Participants

Reaction Steps

N-t-Butoxycarbonyl-3-dimethylaminomethylene-4-piperidone (690 mg, 2.7 mmol) was dissolved in methanol (12 ml), and the solution was mixed with hydrazine monohydrate (160 mg, 3.3 mmol) and heated under reflux for 1 hour. The solvent was removed by evaporation from the reaction solution under a reduced pressure, and the thus obtained material was separated and purified by a silica gel column chromatography to obtain 400 mg (1.8 mmol, 66% in yield) of the title compound.

Provenance & Evidence