4,5,6,7-Tetrahydrothieno(3,2-c)pyridine → HCID 9799318, compound

HRID 2301109Notes

Reaction equation

HRID 2301109 reaction equation
[S:1]1[C:9]2[CH2:8][CH2:7][NH:6][CH2:5][C:4]=2[CH:3]=[CH:2]1.Br[CH2:11][CH2:12][CH2:13][CH2:14][C:15]12[CH2:26][CH2:25][CH2:24][C:22]3[C:23]1=[C:18]([CH:19]=[CH:20][CH:21]=3)[NH:17][C:16]2=[O:27]>>[S:1]1[C:9]2[CH2:8][CH2:7][N:6]([CH2:11][CH2:12][CH2:13][CH2:14][C:15]34[CH2:26][CH2:25][CH2:24][C:22]5[C:23]3=[C:18]([CH:19]=[CH:20][CH:21]=5)[NH:17][C:16]4=[O:27])[CH2:5][C:4]=2[CH:3]=[CH:2]1

Participants

3

Reactant 2

HCID 30850764,5,6,7-Tetrahydrothieno(3,2-c)pyridineHCID 105908942a-(4-Bromobutyl)-2a,3,4,5-tetrahydrobenz[cd]indole-2(1H)-one

Product 1

HCID 9799318HCID 9799318, compound

Procedure

This was synthesized by the same method of Synthesis Example 14c, except that 4,5,6,7-tetrahydro-thieno[3,2-c]pyridine was used instead of 1,2,3,4-tetrahydroisoquinoline and 2a-(4-bromobutyl)-2a,3,4,5-tetrahydro-1H-benz[cd]indol-2-one was used instead of 2a-(4-bromobutyl)-1-methyl-2a,3,4,5-tetrahydro-1H-benz[cd]indol-2-one (yield, 84%).

Sources & evidence

ORD record
ord-3c9ca0050249493084e9da06c9587e87
Source dataset
uspto-grants-2002_12
Patent number
US06498251B1

Reaction notes

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