HCID 18452746, compound → HCID 18519838, compound

Participants

Reaction Steps

To a solution of N-(2,6-dimethylphenyl)-2-(4-{2-hydroxy-3-[(phenylmethoxy)-carbonylamino]propyl}piperazinyl)acetamide in methanol (70 mL) at room temperature was added under a steady flow of nitrogen Pd/C (10% w/w, 0.337 g). Hydrogen gas was bubbled through the reaction mixture via a septum with a needle as outlet for 2 minutes, and the reaction was stirred under a positive hydrogen pressure for two hours. Nitrogen was blown over the suspension before it was filtered over celite. The filtrate was evaporated to give 2-[4-(3-amino-2-hydroxypropyl)piperazin-1-yl]-N-(2,6-dimethylphenyl)acetamide, a compound of formula (6), as a clear oil (2.0 g).

Provenance & Evidence