Ethanol → HCID 18452670, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of 2-[4-(3-amino-2-hydroxypropyl)piperazin-1-yl]-N-(2,6-dimethylphenyl)-acetamide (0.312 mmoles) in ethanol (2 mL) was added triethylamine (100 μL) followed by 2-fluorobenzyl chloride (0.312 mmoles), and the solution was stirred at 90° C. for 18 hours. Solvent was removed under reduced pressure, and the residue purified by preparative TLC, eluting with 5% methanol/dichloromethane, to yield N-(2,6-dimethylphenyl)-2-(4-{3-[(2-fluorophenyl)-carbonylamino]-2-hydroxypropyl}piperazinyl)acetamide, a compound of Formula I.

Provenance & Evidence