HCID 70154690, compound → HCID 18342546, compound

Participants

Reaction Steps

A solution of 2-(R)-(3-(S)-((4-(N-(allyl)-N-(pyrid-3-yl)-amino)-piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-cyclohexaneacetic acid benzyl ester (37 mg, 0.061 mmol from Step C) in 2 mL MeOH was stirred with 13 mg (0.012 mmol) 10% palladium on carbon under 1 atm of hydrogen using a balloon. After 2 h the mixture was filtered and concentrated to provide 30 mg of the title compound. 1H NMR (500 MHz, CDCl3) δ 0.90-0.93 (t, 3H, J=7.5 Hz), 1.1-3.4 (m, 33H), 6.91-6.93 (d, 1H, J=8 Hz), 7.07-7.1 (m, 1H), 7.2-7.35 (m, 5H), 7.92-7.93 (d, 1H, J=4 Hz), 8.08-8.09 (d, 1H, J=2 Hz). ESI-MS. M/z; (M+H)=519.4 (obs), 519.36 (calc.).

Provenance & Evidence