HCID 86758722, compound → HCID 18342549, compound

Participants

Reaction Steps

A solution of 2-(R)-(3-(S)-((4-(N-(prop-1-yl)-N-(pyrimid-2-yl)amino)-piperidin-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-cyclohexylacetic acid, benzyl ester (0.026 ml, 0.24 mmol) from Step A), in 3.0 mL of MeOH was hydrogenated using 10% palladium on carbon (28 mg, 0.026 mmol) under one atmosphere of hydrogen gas. After TLC indicated the absence of the starting benzylester, the reaction was filtered through a 0.45 micron nylon membrane polypropylene filter and concentrated under reduced pressure to give 50 mg (74%) of the title compound as a white solid. HPLC (Zorbax SB-C8 column, 4.6 mm×7.5 cm, Gradient: 90 H2O:10 CH3CN to 0 H2O:100 CH3CN over 7.5 minutes then hold at 100 CH3CN:0 H2O for 45 seconds, 2.25 mL/min, 220 nm): Retention Time: 3.28 minutes. ESI-MS: 520 (M+1).

Provenance & Evidence