HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2301186Generated: November 1, 2026
Potassium Iodide → 1-t-Butyloxycarbonyl-4-(n-cyanomethyl-n-ethylamino)-piperidine
https://huagongshe.com/reaction/2301186
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Potassium Iodide | HCID 4875 | — |
| Reactant | Chloroacetonitrile | HCID 7856 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | tert-Butyl 4-(ethylamino)piperidine-1-carboxylate | HCID 18374730 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-t-Butyloxycarbonyl-4-(n-cyanomethyl-n-ethylamino)-piperidine | HCID 18374709 | 65.5% |
Reaction Steps
To a solution of 150 mg 1-t-butyloxycarbonyl-4-ethylamino-piperidine (from Step A) in 3 ml DCE were added 60 mg of chloroacetonitrile, 109 mg of potassium carbonate, and 11 mg of potassium iodide. The reaction was stirred at 60° C. overnight. Methylene chloride was added, and the solution was washed with 2×20 ml water, and 20 ml brine. The solvent was then evaporated under reduced pressure. The residue was purified by flash chromatography with 20% EtOAc in hexane to give 115 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06498161B1 |
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| Source dataset | uspto-grants-2002_12 |
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| ORD ID | ord-fba84c21a1694e8d908156b838c098e0 |
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| Source note | uspto-grants-2002_12 |
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