Trifluoroacetic acid → HCID 18342539, compound

Participants

Reaction Steps

To 54 mg of 2-(R)-(3-(S)-((4-(N-(2-Benzyl-2H-tetrazol-5-yl)methyl-N-ethylamino)-piperidine-1-yl)methyl)-4-(S)-phenylpyrrolidin-1-yl)-cyclohexaneacetic acid, 4-Methoxybenzyl ester (from Step E) were added 150 mg of anisole and 3 ml of triflouroacetic acid. The reaction was stirred at room temperature for 1 hour. The trifluoroacetic acid was evaporated under reduced pressure. The residue was purified by flash chromatography with 20% MeOH in EtOAc followed by 20% MeOH+2% NH4OH in EtOAc to give 48 mg of the title compound. ESI−MS 601 (M+H).

Provenance & Evidence