Pyridine → HCID 69954038, compound

Participants

Reaction Steps

Benzenesulfonyl chloride (0.528 mL, 4.14 mmol) was added to a cold (0° C.) solution of 6-amino-3-[2-[1-(phenylmethyl)-4-piperidinyl]ethyl]-1,2-benzisoxazole (0.613 g, 4.14 mmol) and pyridine (0.670 mL, 8.28 mmol) in CH2Cl2 (30 mL). After 1.3 hours, saturated sodium bicarbonate (NaHCO3) was added and the resulting mixture was stirred overnight at room temperature. The organic layer was separated and washed with water and brine and dried (MgSO4), filtered, and concentrated. Purification by silica gel flash chromatograph (5% EtOAc/CH2Cl2) gave the title compound (0.867 g, 83%) as a white solid.

Provenance & Evidence