1-Amino-2-methylpropylphosphonic acid, (R)- → (R)-[1-(4'-Chlorobiphenyl-4-sulfonylamino)2-methylpropyl]-phosphonic Acid

Participants

Reaction Conditions

Reaction Steps

250 mg (1.6 mmol) of (R)-(1-amino-2-methylpropyl)phosphonic acid were dissolved in 6 ml of a 1 M NaOH and 6 ml of tetrahydrofuran. 560 mg (1.96 mmol) of 4-chlorobiphenyl-4′-sulfonyl chloride were then added and the mixture was stirred at 22° C. overnight. The reaction mixture was concentrated, acidified with 2 M HCl and extracted with ethyl acetate. The 4-chlorobiphenyl4′-sulfonic acid resulting as a by-product precipitated and was separated off. After drying and concentrating the ethyl acetate phase, a solid was obtained.

Provenance & Evidence