Diphosgene → HCID 18372247, compound

Participants

Reaction Steps

15.4 g (78 mmol) of trichloromethyl chloroformate (“diphosgene”) were added at room temperature to a solution of 22.9 g (97 mmol) of N,N,4-trimethyl-2-(methyl-amino)-1,3-thiazole-5-sulphonamide in 360 ml of dioxane, and the mixture was heated to reflux until a homogeneous solution was obtained, and TLC showed that no starting material remained. After removal of the solvent in vacuo, 29.0 g of the product were obtained in the form of an oil. (Yield 100%, NMR (CDCl3): 3.89 (3H), 2.81 (6H), 2.62 (3H) ppm).

Provenance & Evidence