反应详情

To a solution of 0.5 g (2.9 mmol) of 3-tert-butyloxycarbonylaminopropylamine in 8 ml of DCM and 0.37 g (2.9 mmol) of NEM was added a solution of 0.32 g (0.29 mmol) of ethyl chloroformate in 2 ml of DCM. After 24 h at RT the mixture was washed with water and dried. The solvent was evaporated and the residue was stirred with 5 ml of TFA (90%). After 1 h the solvent was evaporated to give 0.6 g of the title compound. MS=147.0 (M+1)+.

1. washAfter 24 h at RT the mixture was washed with water
2. customdried
3. customThe solvent was evaporated
4. customAfter 1 h the solvent was evaporated