HCID 15524163, compound → HCID 15524166, compound

HRID 2301299Notes

Reaction equation

HRID 2301299 reaction equation
C([O:5][C:6]([CH2:8][NH:9][C:10]1[CH:11]=[C:12]([S:16]([NH2:19])(=[O:18])=[O:17])[CH:13]=[CH:14][CH:15]=1)=[O:7])(C)(C)C.[Cl:20][C:21]1[CH:22]=[C:23]([NH:31][C:32](OC2C=CC=CC=2)=[O:33])[C:24](=[CH:29][CH:30]=1)[C:25](OC)=[O:26]>>[C:6]([CH2:8][NH:9][C:10]1[CH:11]=[C:12]([S:16]([N:19]2[C:25](=[O:26])[C:24]3[C:23](=[CH:22][C:21]([Cl:20])=[CH:30][CH:29]=3)[NH:31][C:32]2=[O:33])(=[O:17])=[O:18])[CH:13]=[CH:14][CH:15]=1)([OH:5])=[O:7]

Participants

3

Reactant 2

HCID 15524163HCID 15524163, compoundHCID 22347487HCID 22347487, compound

Product 1

HCID 15524166HCID 15524166, compoundYield 9%

Procedure

1.62 g (5.65 mmol) of 3-t-butoxycarbonylmethylaminobenzenesulfonamide and 1.73 g (5.65 mmol) of methyl 4-chloro-2-N-phenoxycarbonylanthranilate were treated in the same way as in Preparation Example 7 to obtain 209 mg (yield 9%: 4 steps) of the above-identified compound. Properties: colorless crystal, Melting point: >200° C. (decomposition), PMR (δ ppm, DMSO-d6): 3.86 (2H, s), 6.88 (1H, s), 7.12 (1H, s), 7.24 (1H, d), 7.30-7.38 (3H, m), 7.86 (1H, d), 11.61 (1H, br).

Workup

  1. customto obtain 209 mg (yield 9%: 4 steps) of the above-identified compound

Sources & evidence

ORD record
ord-da9a2877461b4f04b234bd6f93772090
Source dataset
uspto-grants-2002_12
Patent number
US06500835B2

Reaction notes

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