Bromine → HCID 18344919, compound

Participants

Reaction Steps

To a solution of 5-ethoxycarbonylmethyl-2-methyl-1H-indole-3-carboxylic acid ethyl ester (3 g, 10.4 mmol) in acetic acid (20 mL) is added bromine (1.65 g, 10.4 mmol) dropwise, and the reaction mixture is stirred for 10 minutes. The solution is then concentrated in vacuo and chromatographed with a gradient of hexane/ethyl acetate (5%-30%) within 30 minutes to afford a yellow solid (3.3 g, 86%). MS: 368, 370 (M+1)+.

Provenance & Evidence