Ethanol → HCID 334589, compound

HRID 2301342Notes

Reaction equation

HRID 2301342 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:5]=1[OH:11])=[O:3].[CH:12]1[C:17]([CH:18]=O)=[CH:16][C:15]2[O:20][CH2:21][O:22][C:14]=2[CH:13]=1.[OH-].[Na+].C(O)C>O>[O:22]1[C:14]2[CH:13]=[CH:12][C:17]([CH:18]=[CH:1][C:2]([C:4]3[CH:9]=[C:8]([Cl:10])[CH:7]=[CH:6][C:5]=3[OH:11])=[O:3])=[CH:16][C:15]=2[O:20][CH2:21]1

Participants

6

Reactant 4

HCID 702EthanolHCID 8438PiperonalHCID 14798Sodium HydroxideHCID 740613-Chloro-6-hydroxyacetophenone

Product 1

HCID 334589HCID 334589, compoundYield 80%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

1 g (5.86 mmol) of 5-chloro-2-hydroxyacetophenone, 3 molar equivalents of piperonal, and 3 molar equivalents of sodium hydroxide was mixed in 15 ml of aqueous 80% ethanol solution, and then the mixture was stirred at room temperature for 15 hours. After the reaction was completed, 50 ml of water was added thereto, and the mixture was stirred for about 10 minutes. The obtained pale yellow solid was filtered, washed with water and diethylether, and dried to give 1.42 g (Yield 80%) of the title compound.

Workup

  1. stirringthe mixture was stirred for about 10 minutes
  2. filtrationThe obtained pale yellow solid was filtered
  3. washwashed with water and diethylether
  4. customdried

Sources & evidence

ORD record
ord-4250d61c4808477c86e825c51ddbef42
Source dataset
uspto-grants-2002_12
Patent number
US06500846B1

Reaction notes

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