Sodium Acetate → 7-Methoxyflavone

HRID 2301344ノート

反応式

HRID 2301344 の反応式
O[C:2]1[CH:7]=[C:6]([O:8][CH3:9])[CH:5]=[CH:4][C:3]=1[C:10](=[O:20])[CH2:11][C:12]([C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1)=[O:13].C([O-])(=O)C.[Na+]>C(O)(=O)C>[CH3:9][O:8][C:6]1[CH:5]=[C:4]2[C:3]([C:10](=[O:20])[CH:11]=[C:12]([C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[O:13]2)=[CH:2][CH:7]=1

参加物

4

反応物 2

HCID 517045Sodium AcetateHCID 114145481-(2-Hydroxy-4-methoxyphenyl)-3-phenylpropane-1,3-dione

生成物 1

HCID 4662687-Methoxyflavone収率 70%

試薬・触媒・溶媒 1

HCID 176Acetic Acid溶媒

実験手順

240 mg (0.89 mmol) of 1-(2-hydroxy-4-methoxy-phenyl)-3-phenyl-propan-1,3-dione was dissolved in acetic acid, and 0.73 g (8.9 mmol) of sodium acetate was added thereto. The mixture was refluxed overnight. Acetic acid was removed by distillation under reduced pressure, and then the residue was purified by silica gel column chromatography (eluent: n-hexane/ethylacetate=5/1, v/v) to give the title compound in a yield of 70%.

後処理

  1. temperatureThe mixture was refluxed overnight
  2. customAcetic acid was removed by distillation under reduced pressure
  3. customthe residue was purified by silica gel column chromatography (eluent

出典と根拠

ORDレコード
ord-59fd021b16774d859d824e784f15c118
出典データセット
uspto-grants-2002_12
特許番号
US06500846B1

反応ノート

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