反应详情

温度

0 °C

A solution of 5-fluoro-8-hydroxyquinoline (0.50 g) in 4.0 mL of chlorosulfonic acid is stirred for 3 h at 90° C. and then 13 h at 105° C. The mixture is then cooled to 0° C. and poured onto 50 mL of finely divided −15° C. ice. The bright orange-red precipitate is collected by filtration, washed with four 10-mL portions of 0° C. distilled water and three 2 mL portions of diethyl ether, and dried in a stream of air to give 0.208 g of the title compound as a red-orange powder.

1. custom13 h
2. customat 105° C
3. additionpoured onto 50 mL of finely divided −15° C. ice
4. filtrationThe bright orange-red precipitate is collected by filtration
5. washwashed with four 10-mL portions of 0° C.
6. distillationdistilled water and three 2 mL portions of diethyl ether
7. customdried in a stream of air