反应详情

A solution of 2-acetyl6-chloro-3-nitrobenzenesulfonamide (1.72 g, 5.83 mmol), chlorotrimethylsilane (2 mL) and fuming sulfuric acid (0.5 mL) in methanol was heated to reflux for 20 hours. The solvent was evaporated. The residue was diluted with ethyl acetate and washed with water. The organic layer was then dried (Na2SO4) and concentrated to give the desired product (1.0 g, 68%). EI-MS (m/z) 251.1, 253.2 (M−).

1. temperatureto reflux for 20 hours
2. customThe solvent was evaporated
3. additionThe residue was diluted with ethyl acetate
4. washwashed with water
5. dry with materialThe organic layer was then dried (Na2SO4)
6. concentrationconcentrated