HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Peroxide → 1,3-Dioxaindane-4-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 1,3-Benzodioxole-4-carboxaldehyde | HCID 82264 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 1,3-Dioxaindane-4-carboxylic acid | HCID 304832 | 96.5% |
Reaction Steps
A solution of 2,3-(methylenedioxy)benzaldehyde (160mg, 1.06mmol), potassium carbonate (960 mg, 6.9 mmol) and 2.4mL of hydrogen peroxide (30-32 wt.% solution in water) in 10 mL of methanol was stirred for 16 hours at room temperature. The mixture was washed with diethyl ether. The water layer was acidified with 1 N aq. HCl to pH>1, then extracted with ethyl acetate. The organic layer was dried over MgSO4, then concentrated to give the desired product (170mg, 96%). EI-MS (m/z) 164.8 (M−).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06500863B1 |
| Source dataset | uspto-grants-2002_12 |
| ORD ID | ord-322973f0b4604d3fb06ecad27fc8b285 |
| Source note | uspto-grants-2002_12 |